![]() ![]() ![]() 1– 3 This is accompanied by hypoalbuminemia, hyperlipidemia, and generalized edema. Nephrotic syndrome (NS) is the commonest chronic glomerular disease in children characterized by heavy proteinuria. The scope of the NHIS can be expanded to cater for the expensive bill of genetic testing within or outside the structure of the National Renal Care Policy proposed by Nigerian nephrologists. Concerted efforts can be put in place to increase the number of enrollees in Nigeria’s National Health Insurance Scheme (NHIS). For these children to benefit from genetic diagnosis, Nigeria must aspire to have and develop the manpower and infrastructure required for medical genetics and genomic medicine, leveraging on her existing experiences in genomic medicine. This article describes the genetics of NS/SRNS in childhood and also gives a narrative review of the challenges and opportunities for molecular testing among children with SRNS in Nigeria. Therefore, a multidisciplinary collaboration among cell biologists, molecular physiologists, geneticists, and clinicians holds prospects of fine-tuning the management of SRNS caused by known mutant genes. Monogenic FSGS is primarily resistant to steroids, and this foreknowledge obviates the need for steroids, other immunosuppressive therapy, and renal biopsy. With the advent of next-generation sequencing, >39 genes are currently associated with SRNS, and the number is likely to increase in the near future. While knowledge of the molecular basis of NS is evolving, recent data support the role of mutant genes that otherwise maintain the structural and functional composition of the glomerular filtration barrier to account for many monogenic forms of FSGS. FSGS tends to progress to end-stage kidney disease, which requires dialysis and/or renal transplantation. This steroid resistance among Nigerian children also reflects underlying renal histopathology, revealing a rare minimal-change disease and a varying burden of membranoproliferative glomerulonephritis and focal segmental glomerulosclerosis (FSGS). Software To Edit Video Clips Free Demo ResourcesDownload Free Download Free x By Team Product Collaborate better and ship faster Engineering Improve documentation, bug reports, and code reviews Customer Support Close tickets faster with visuals Sales Personalize customer engagements Education Collaborate and share easier Designers Speed up design work Marketing Create collateral and improve collaboration Workflow Customer Experience Create the best experience possible with faster internal and external comms Remote Work Collaborate better and skip unnecessary meetings Project Management Add depth to projects with visuals Productivity Save time by skipping a meeting or long email and sending a video instead Watch free demo Resources Community use cases, case studies and eBooks on best practices, and tools and workflows to help you work at the speed of sight.The prevalence of childhood steroid-resistant nephrotic syndrome (SRNS) ranges from 35% to 92%. Software To Edit Video Clips Free DownIoad FreeDownload Free DownIoad Free Féatures Pricing lntegrations x Capture Recording Scréenshots Annotations GIF Makér Share Viewer Embédding Interactivity Host Sháring Grow SEO AnaIytics CTAs Notifications Managé Security Collaboration Téams Solutions CloudApp providés instant collaboration fór individuals and énterprise teams through sharabIe screenshots, screen récording videos, and GlFs. Become more productive and save up to 56 hours a week with CloudApp 2.
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